He is perhaps best known as an author of children's books, which he turned to on behalf of a niece, Janet Hart White. His first children's book, "Stuart Little", was published in 1945. It is the tale of a young New Yorker named Stuart Little who had the "shy, pleasant manner of a mouse" and in Garth William's illustrations does look like a mouse and by the time the three highly successful Stuart Little films were made, had become a mouse.
"Charlotte's Web", published in 1952, tells the story of a barn spider named Charlotte and her friendship with a pig named Wilbur. The illustrator again was Garth Williams. In 2000 Publishers Weekly acclaimed the book as the best-selling children's paperback of all time. Written in White's dry, low key manner, "Charlotte's Web" is considered a classis of children's literature, enjoyable to adults as well as children.